Hepatitis B Annual

Current Issue  

Back Issues   


Search Login    Users online: 378 Print this page  Email this page Small font sizeDefault font sizeIncrease font size 
>>> Ahead of Print <<<
Year : 2008  |  Volume : 5  |  Issue : 1  |  Page : 12-22

Flares on and off therapy during chronic HBV infection: Pathogenesis, significance and management

Department of Gastroenterology, Bombay Hospital and Medical Research Centre, Mumbai, India

Correspondence Address:
Deepak N Amarapurkar
Ameya Society, New Prabhadevi Road, Prabhadevi, Mumbai 400 025
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9747.58803

Rights and Permissions

Approximately 400 million people worldwide are chronically infected with the hepatitis B virus (HBV). Chronic infection with HBV can lead to progressive liver diseases including cirrhosis, liver failure, and hepatocellular carcinoma. During treatment of chronic hepatitis B (CHB) patients, flares of inflammatory activity are a well known phenomenon. Flares can be life threatening but have also been associated with virological response. While, interferon induced flares have been attributed to the stimulatory effect of IFN, and may precede HBeAg seroconversion, Lamivudine related flares are seen during treatment and after withdrawal of lamivudine, which are probably caused by reoccurrence of HBV replication, and have been associated with decompensation of liver disease. These flares play an important role in the treatment with Peg-IFN α-2b alone or in combination with lamivudine, and patients with pre-existing cirrhosis are at greater risk for experiencing a flare. Furthermore, host induced flares but not virus induced flares may herald a response to therapy. For optimisation of treatment, it is necessary to understand the virological and immunological mechanisms which induce the specific flare patterns. This article reviews the pathogenesis, significance and management of flares encountered during and after cessation of treatment of patients with chronic HBV infection.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded1001    
    Comments [Add]    
    Cited by others 1    

Recommend this journal