| REVIEW ARTICLE |
|
| Year : 2009 | Volume
: 6
| Issue : 1 | Page : 131-140 |
|
|
HBeAg negative chronic Hepatitis B: An overview
Mamun-Al-Mahtab1, SM Fazle Akbar2
1 Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, and Viral Hepatitis Foundation, Bangladesh
2 Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan
Correspondence Address:
Mamun-Al-Mahtab
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka
Bangladesh
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0972-9747.76910
|
|
|
Over 350 million people worldwide are infected with hepatitis B virus (HBV), and patients with HBeAg-negative chronic hepatitis B constitute a major proportion of this population. Mutant varieties of HBV resulting from mutations in the precore or core promoter region of the viral genome give rise to HBeAg-negative CHB, and these cases must be differentiated from the inactive carrier state. These patients with HBeAg-negative CHB must be managed judiciously and in certain situations kept under close follow-up instead of rushing to treatment. However, this does not mean advocating adoption of a too conservative approach, allowing many to proceed to irreversible and progressive liver disease. This article provides an overview of the management of HBeAg-negative chronic hepatitis B. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
