Hepatitis B Annual

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Year : 2009  |  Volume : 6  |  Issue : 1  |  Page : 131-140

HBeAg negative chronic Hepatitis B: An overview

1 Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, and Viral Hepatitis Foundation, Bangladesh
2 Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan

Correspondence Address:
Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9747.76910

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Over 350 million people worldwide are infected with hepatitis B virus (HBV), and patients with HBeAg-negative chronic hepatitis B constitute a major proportion of this population. Mutant varieties of HBV resulting from mutations in the precore or core promoter region of the viral genome give rise to HBeAg-negative CHB, and these cases must be differentiated from the inactive carrier state. These patients with HBeAg-negative CHB must be managed judiciously and in certain situations kept under close follow-up instead of rushing to treatment. However, this does not mean advocating adoption of a too conservative approach, allowing many to proceed to irreversible and progressive liver disease. This article provides an overview of the management of HBeAg-negative chronic hepatitis B.

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