%A , Mamun-Al-Mahtab %A Fazle Akbar, S %T HBeAg negative chronic Hepatitis B: An overview %9 Review Article %D 2009 %J Hepatitis B Annual %R 10.4103/0972-9747.76910 %P 131-140 %V 6 %N 1 %U https://www.hepatitisbannual.org/article.asp?issn=0972-9747;year=2009;volume=6;issue=1;spage=131;epage=140;aulast=Mamun-Al-Mahtab, %8 January 1, 2009 %X Over 350 million people worldwide are infected with hepatitis B virus (HBV), and patients with HBeAg-negative chronic hepatitis B constitute a major proportion of this population. Mutant varieties of HBV resulting from mutations in the precore or core promoter region of the viral genome give rise to HBeAg-negative CHB, and these cases must be differentiated from the inactive carrier state. These patients with HBeAg-negative CHB must be managed judiciously and in certain situations kept under close follow-up instead of rushing to treatment. However, this does not mean advocating adoption of a too conservative approach, allowing many to proceed to irreversible and progressive liver disease. This article provides an overview of the management of HBeAg-negative chronic hepatitis B. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0972-9747